Evidence-Based Clinical Practice · Peer-Informed Research
Journal of Healthspan Medicine & Clinical Prevention
Physician-authored analysis of clinical trials, biomarker protocols, cardiometabolic health, and proactive disease prevention.
Featured Dispatch · Geromedicine
What Is Intrinsic Capacity? The Metric Transforming Preventive Geromedicine
What is intrinsic capacity? A physician explains the WHO framework measuring physical and mental reserve, its core domains, and how it is transforming preventive geromedicine.
Michael Leone, MD · Physician & Co-Founder
September 3, 2026 · 6 min read
The Overlooked Pillar of Physical Healthspan: Why Joint Range of Motion and Movement Capacity Matter as We Age
Why is joint range of motion crucial for physical longevity? A physician explores the Sitting-Rising Test mortality data, the LIFE study, and 4 practical mobility exercises.
Acarbose as a Gerotherapeutic: What the ITP Data and Clinical Trials Actually Show
Why did acarbose extend male mouse lifespan by 22% in NIA trials? A physician examines the ITP data, human diabetes prevention, and clinical cardiovascular outcomes.
Galleri and MCED Tests vs. Standard Screening: What Actually Reduces Cancer Mortality?
Is the Galleri multi-cancer blood test worth it? A physician breaks down MCED trial data, Stage I sensitivity, and why blood tests cannot replace standard cancer screening.
Normal LDL-C but High ApoB: The Hidden Risk of Lipid Discordance
Normal LDL-C but high ApoB? A physician explains lipid discordance, small dense LDL, and why standard cholesterol panels can miss true cardiovascular risk.
The Top 3 Longevity Clinics: An Evidence-Based Medical Audit
Are high-end longevity clinics worth the cost? A physician audits Fountain Life, Human Longevity Inc., and Prenuvo on diagnostics, pricing, and clinical evidence.
DTC "Shotgun" Lab Panels: The Flawed Science of 100-Biomarker Testing
Are 100-biomarker direct-to-consumer blood tests worth it? A physician explains the math of false positives, diagnostic cascades, and why targeted testing is superior to shotgun panels.
Lean Insulin Resistance: Why Normal-Weight Individuals Develop Type 2 Diabetes
Can you be thin and have type 2 diabetes? A physician explains lean insulin resistance, the personal fat threshold, the Asian phenotype, and how to manage normal-weight diabetes.
Compressing Morbidity: How Healthspan Medicine and Geromedicine Protect Our Final Decades
Why is modern healthcare failing our final years? A physician explains the compression of morbidity, the three physiological reserves, and how geromedicine targets biological aging.
The Science of Sleep Supplements: What Clinical Research Actually Supports
Which sleep supplements actually work? A physician breaks down the clinical research, mechanisms, and evidence-based dosages for melatonin, glycine, L-theanine, and magnesium.
Is Zone 2 Cardio Over-Hyped? What the Science Really Says About Aerobic vs. High-Intensity Training
Is Zone 2 training really the holy grail of cardiovascular fitness? A physician breaks down the science of Zone 2 vs. HIIT, VO2 max, and how to balance your training.
The Accuracy of Wearable Health Devices: A Clinician’s Guide to the Data
How accurate is your Apple Watch, Oura Ring, or Whoop? A physician explains the science of wearable accuracy, precision, HRV, sleep stages, and clinical utility.
Senolytics in Geroscience: Can Clearing "Zombie Cells" Improve Human Healthspan?
Can clearing senescent cells slow biological aging? A physician explores the mechanisms, clinical trials, benefits, and risks of senolytics in geroscience.
Coronary Artery Calcium (CAC) Scans: Refining Cardiovascular Risk with Direct Imaging
What does your coronary calcium score mean? A physician explains how CAC scans work, what Agatston score categories indicate, radiation safety, cost, and differences from CCTA.
The Whack-a-Mole Problem in Modern Medicine: Why the Future of Healthcare Depends on Geroscience
Why does modern medicine treat diseases in isolation? A physician explains the geroscience hypothesis, morbidity compression, and why funding basic aging biology is essential.
Why Prevention Is Our Most Powerful Weapon Against Alzheimer’s Disease
Can Alzheimer's disease be prevented? A physician breaks down why current medications are limited and details evidence-based lifestyle, vascular, and metabolic strategies to protect brain health.
Spotting Insulin Resistance Early: Beyond Fasting Glucose and HbA1c
Why do standard blood sugar labs miss early insulin resistance? A physician breaks down HOMA-IR, fasting insulin, CGMs, and early metabolic screening strategies.
Why Healthspan Medicine Must Become a Recognized Medical Specialty
Why is primary care constrained in proactive prevention? A physician breaks down why healthspan medicine must become a recognized specialty, bridging evidence-based cardiology, exercise physiology, and geroscience.
SGLT2 Inhibitors as Gerotherapeutics: From Diabetes Medications to Longevity Candidates
Can diabetes drugs slow biological aging? A physician breaks down SGLT2 inhibitors, their preclinical lifespan data, hallmarks of aging, and human clinical trials.